GLUCOPHAGE (metformin hydrochloride tablets)
GLUCOPHAGE XR (metformin hydrochloride
extended-release tablets)

Oral Antidiabetes Medications (FDA Consumer magazine, January-February 2002)

Diabetic Neuropathy: An Intensive Review

Diabetes and Macrovascular Disease: Risk Factor Management
The Impact of Cardiovascular Disease
What We Know About the Endothelium
Vasculoprotection With Nitric Oxide
The Role of Oxidative Stress in Endothelial Dysfunction and Vascular Disease
The Renin-Angiotensin System: A Major Role in Endothelial Function
Putting It All Together: The Path to Coronary Artery Disease
Endothelial Dysfunction: Causes and Treatment Strategies
Plaque Pathology: An Inside View
Diabetes: A Source of Endothelial Insult
Reducing Macrovascular Complications: Evidence From the Statin Trials
More on the Vasculoprotective Effects of Lipid Lowering With Statins
Reducing Macrovascular Complications: Evidence From the Angiotensin-Converting Enzyme Inhibitor Trials
Findings From the Heart Outcomes Prevention Evaluation
Vasculoprotection With Angiotensin-Converting Enzyme Inhibitors
The Current Views on Risk Reduction Therapy

Cross-Talk Between Iron Metabolism and Diabetes
Emerging scientific evidence has disclosed unsuspected influences between iron metabolism and type 2 diabetes. The relationship is bi-directional—iron affects glucose metabolism, and glucose metabolism impinges on several iron metabolic pathways. Oxidative stress and inflammatory cytokines influence these relationships, amplifying and potentiating the initiated events. The clinical impact of these interactions depends on both the genetic predisposition and the time frame in which this network of closely related signals acts

Iron Stores in Healthy Women Linked to Diabetes Risk

Feb. 10, 2004 — Higher amounts of iron stores in the blood are associated with an increased risk of type 2 diabetes in healthy women with no known diabetes risk factors, according to the results of a nested case-control trial published in the Feb. 11 issue of The Journal of the American Medical Association.

Daily Multivitamin/Mineral Supplement Reduces Infection in Type 2 Diabetes

Chromium Supplements Appear to Improve Glucose Sensitivity in Diabetics

Sweet Potato Extract Improves Glycemic Control in Type 2 Diabetes

Diabetes Care: Small-Bowel Bacterial Overgrowth in Diabetic Subjects Is Associated With Cardiovascular Autonomic Neuropathy.: "Gastrointestinal symptoms are present in 50-70% of patients with diabetes. Delayed gastric emptying, and disturbance of intestinal motility are frequent findings [1,2]. Impaired intestinal motility is often followed by small-bowel bacterial overgrowth (SBBO), which can possibly lead to deconjugation of bile acids, diarrhea, "

Medscape Resource Center - Diabetic Microvascular Complications: "Diabetes is, of course, a disease of complications. But landmark studies such as the Diabetes Control and Complication Trial have shown that achieving tight glycemic control can directly reduce the risk of diabetic complications, especially diabetic microvascular complications. New screening tools and potential new treatments also hold promise for making diabetic microvascular complications such as retinopathy and neuropathy more manageable and less inevitable."