Monday, December 27, 2004

Depression May Raise Women's Diabetes Risk

Depression May Raise Women's Diabetes Risk
Symptoms of Depression Linked to Insulin Resistance

By Jennifer Warner
Reviewed By Brunilda Nazario, MD
on Wednesday, December 22, 2004
WebMD Medical News

Dec. 22, 2004 -- Feeling blue may raise women's risk of developing type 2 diabetes, according to new research.

The study shows that symptoms of depression in middle-aged women are associated with higher levels of insulin resistance, which is a precursor to diabetes.

Researchers say the findings may help explain why depression is twice as common among people with diabetes compared with the general population. Depression is also associated with poor diabetes management.

Depression and Diabetes Linked

In the study, which appears in the December issue of Diabetes Care, researchers looked at the association between symptoms of depression and diabetes among a group of 2,662 middle-aged women who took part in the Study of Women's Health Across the Nation. All of the women were free of diabetes when the study began.

Three years later, 97 cases of diabetes were diagnosed among the women.

Researchers found that depression predicted a 66% greater risk of diabetes in the women, but this association disappeared after they adjusted for other risk factors associated with the development of diabetes, such as excess fat around the midsection (a heart disease and type 2 diabetes risk factor known as central adiposity).

However, symptoms of depression were linked to greater levels of insulin resistance among the women.

In addition, depressed African-American women were more than 2.5 times more likely to develop diabetes, even after adjusting for other risk factors.

Researchers say the results show that depressive symptoms can increase the risk of diabetes and are related to higher levels of insulin resistance -- another risk factor for diabetes.

They add that depression can alter hormones relating to how the body handles stress. This in turn can affect body fat distribution and how it handles blood sugar metabolism.

They say people should be encouraged to seek treatment for depression and maintain and adopt active lifestyles, healthy diets, and weight loss, if needed, to reduce their risk of diabetes.

SOURCE: Everson-Rose, S. Diabetes Care, December 2004; vol 27: pp 2856-2862.

A Nutty Way to Improve Cholesterol in Diabetes

A Nutty Way to Improve Cholesterol in Diabetes
Eating a Healthy Diet Including Walnuts May Reduce Type 2 Diabetes Risks

By Jennifer Warner
Reviewed By Brunilda Nazario, MD
on Friday, December 03, 2004
WebMD Medical News

Dec. 3, 2004 -- Incorporating a handful of walnuts into a healthy diet may help people with type 2 diabetes improve their cholesterol levels and reduce their risk of heart disease, a new study suggests.

Researchers found including walnuts as part of a balanced, low-fat diet helped people with diabetes increase their "good" HDL cholesterol levels while lowering their "bad" LDL cholesterol levels.

But don't reach for the nut bowl just yet. Experts say merely adding walnuts to an already unhealthy diet won't necessarily undo the damage. Instead, they say it's important to substitute walnuts for other sources of fat in the diet in order to achieve the best results.

Walnuts contain an omega-3 fatty acid called alpha-linolenic acid or ALA, which is similar to the omega-3 fatty acids found in fatty fish, such as salmon. Previous studies have shown that alpha-linolenic acid has a number of heart-healthy effects, including improving cholesterol levels.

Researchers say this is one of the first studies to look at the effects of the fatty acids found in walnuts in people with type 2 diabetes.

Walnuts May Aid in Diabetes Management

In the study, which appears in the December issue of Diabetes Care, researchers looked at the effects of three different diets on cholesterol levels in older adults with type 2 diabetes.

Nearly 60 men and women were divided into three groups that followed three different diet plans: a low-fat diet, a modified-fat diet, or a modified-fat diet that included eight to 10 walnuts per day (30 grams). All of the diets were based on eating a variety of whole foods, such as cereals and breads, fruits and vegetables, lean meat, fish, and low-fat dairy products with no more than 30% of total calories from fat.

After six months of the diet, the results showed that the people who ate the modified-fat diet including walnuts experienced a bigger increase in "good" HDL cholesterol levels than those in the other two diets. People who ate walnuts as part of a balanced diet also experienced an average 10% reduction in "bad" LDL cholesterol levels.

Researchers say the study suggests that incorporating walnuts into a healthy diet may be an easy way for people with type 2 diabetes to get the right kinds of fats and fatty acids into their diet.

"Walnuts are an easy and convenient way of getting polyunsaturated omega-3 fatty acids into the diet. And they're particularly important for people with diabetes because they're a simple snack food, which is an integral component of managing the diet in diabetes," says researcher Linda Tapsell, PhD, of the University of Wollongong in Australia, in a news release.

Although the walnut diet appeared to help improve cholesterol levels in people with type 2 diabetes, no significant differences were found between the groups in terms of body weight or body fat.

Funding for the study was provided by the California Walnut Commission.

Hyperglycemia Slows Mental Functions in People with Diabetes

ALEXANDRIA, VA -- December 22, 2004 -- A temporary rise in blood glucose (sugar) levels in people with both types of diabetes can interfere with their ability to think quickly and solve problems, according to a study in the January issue of Diabetes Care.

Researchers at the University of Virginia Health System (UVHS) found that people who had both type 1 and type 2 diabetes performed poorly on math and verbal tests when they became hyperglycemic, a condition in which blood glucose levels are higher than normal. Symptoms of hyperglycemia include high blood glucose, high levels of sugar in the urine, frequent urination, and increased thirst. Roughly 55 percent of the people in the study showed signs of cognitive slowing or increased errors while hyperglycemic, suggesting that the consequences of hyperglycemia vary among individuals. However, among those whose cognitive performance deteriorated when blood sugar levels rose, the negative effects consistently appeared once levels reached or exceeded a threshold of 15 mmol/l or 270 mg/dl.

Because hypoglycemia (when blood glucose levels are too low) can cause dizziness and an inability to focus, many people consume large amounts of carbohydrates to avoid this state prior to school exams and other cognitive- sensitive tasks. But this study suggests that carbohydrate-loading could be counterproductive, the researchers conclude, because hyperglycemia often occurs after overeating.

"The best way to minimize any negative effects on cognitive functioning is to keep blood glucose levels tightly controlled," said lead researcher Dr. Daniel J. Cox, of the Center for Behavioral Medicine Research at UVHS. "People who have diabetes should pay careful attention to the warning signs of hyperglycemia so that they can quickly take action to treat it."

Treatment for hyperglycemia can include increasing insulin or reducing food intake.

SOURCE: American Diabetes Association

Wednesday, December 15, 2004

BioMed Central | Full text | Update on Charcot Neuroarthropathy: "Charcot neuroarthropathy is not uncommon in diabetic patients with peripheral neuropathy. Often, the condition is misdiagnosed for cellulitis or osteomyelitis and treatment is delayed. A high index of suspicion is required in these patients to initiate appropriate treatment early. This article covers the pathogeneses of this condition and briefly describes the recent studies performed to understand the underlying etiopathogenetic factors of this devastating condition. Lastly, it mentions the recently completed multicenter trial using bisphosphonates in diabetic Charcot neuroarthropathy."

Saturday, December 11, 2004

Diabetic Gourmet Magazine - Dedicated to Diabetic Dining and Healthy Living
Diabetic Gourmet Magazine: free newsletter, daily tidbits, menus and forum. "
Sponsored by GlaxoSmithKline

Welcome to Diabetes.comYou Can Be Stronger Than Diabetes"
David Mendosa: A Writer on the Web: "Diabetes is a disease that perhaps more than any other depends much more on the patient than on the doctor. If you are newly diagnosed with diabetes, please start with Advice for Newbies. I have written hundreds of magazine and on-line articles, columns, and Web pages about diabetes, most of which are listed and linked in my Diabetes Directory. This includes the 15 pages of my On-Line Diabetes Resources,"
Diabetes Resource Center: "Welcome to the Diabetes Resource Center! This site was developed by Eli Lilly and Company. The purpose of this resource center is to provide easy steps for healthy foot care. By increasing the importance of daily foot exams, most diabetic foot ulcers and amputations can be prevented" | Diabetes: "Diabetes | Links
You are visiting Sarahealth, the site dedicated to achieving optimal physical and emotional wellness. This page discusses Type 2 diabetes with a focus on self-education and self-management."

Monday, December 06, 2004

The Brownsville Herald � Study on diabetes surpasses anticipated figures
Dec. 6, 2004 — Elida Ortiz blames a poor diet and sedentary lifestyle for her diabetes, but the odds may have been stacked against her.

“You are what you eat,” said Ortiz who was diagnosed with Type II diabetes four years ago.

“I used to eat three of four flour tortillas or six corn tortilla tacos (per meal),” said 59-year-old Ortiz, “I needed to change that.”

Lifestyle choices, such as a high-fat, high-sugar diet and lack of exercise, can trigger diabetes in individuals that carry the disease.

Sunday, December 05, 2004

Vitamin E Helps Some Diabetes Patients - Trustworthy, Physician-Reviewed Information from WebMD: "Nov. 23, 2004 -- Some people with diabetes may benefit from taking vitamin E, according to an international team of scientists.

Vitamin E's possible heart benefits are described in a letter published in the November issue of the journal Diabetes Care. The letter was written by researchers, including Andrew Levy, MD, PhD, of Technion-Israel Institute of Technology in Haifa, Israel."

Friday, December 03, 2004

Title: Testosterone Deficiency Found in One-Third of Diabetic Men
"Testosterone Deficiency Found in One-Third of Diabetic Men"

Study is first to reveal hypogonadism as common complication of diabetes BUFFALO, NY -- November 29, 2004 -- Low testosterone production appears to be a common complication of type 2 diabetes in men, affecting 1 out of 3 diabetic patients, a new study has shown. Moreover, results of the investigation show that this condition, known clinically as hypogonadism, is caused not by a defect in the testes, where testosterone is produced, but by improper functioning of the pituitary gland, which controls production of testosterone, or of the hypothalamus, the region of the brain that controls the pituitary. "This starts a whole new story on the crucial complications of type 2 diabetes," said Paresh Dandona, M.D., senior author on the study and director of the Division of Endocrinology, Diabetes and Metabolism at the University at Buffalo and Kaleida Health, where the study was conducted. Results of the study appear in the November issue of Journal of Clinical Endocrinology and Metabolism. Sandeep Dhindsa, M.D., UB assistant professor of medicine and first author on the study, said the findings are important because hypogonadism has not been recognized as a complication of type 2 diabetes, and the high prevalence of 30 percent was unexpected. "The surprisingly high prevalence of low testosterone levels was associated with lower levels of pituitary hormones called gonadotrophins, suggesting that the primary defect in these patients was either in the pituitary or higher up in the hypothalamus," he said. "Since gonadotrophins drive the testes to produce testosterone, this finding gives us an insight into the pathogenesis of this complication of type 2 diabetes." Earlier studies, including those conducted by this research group, found that diabetic subjects with erectile dysfunction and low testosterone levels often have low levels of pituitary hormones. However, conclusions from prior studies have been fraught with problems with testosterone assays, Dhindsa noted. "A large portion of testosterone in the blood is bound to proteins, but a small portion is unbound and largely determines the amount of testosterone that is available to the tissues," said Dhindsa. "This active portion is called free testosterone. Assays to accurately determine it are delicate, tedious and time-consuming. "This investigation set out to determine, in a prospective fashion, the prevalence of low total testosterone, accurately measure free testosterone in male patients with type 2 diabetes and to attempt to determine the seat of the problem in those with low free testosterone." The study involved 103 consecutive males with type 2 diabetes who were referred to the Diabetes-Endocrinology of Western New York for treatment. None of the men had been diagnosed previously with low testosterone levels. The researchers collected fasting blood samples from the participants and analyzed them for testosterone levels and for hormones associated with testosterone production. They also measured cholesterol and glucose levels, and a blood marker for how well glucose was controlled during previous months, called hemoglobin A1c. Data on height, weight and diabetic complications, including erectile dysfunction, neuropathy, retinopathy and coronary artery disease, were recorded. Results showed that nearly one-third of the men had hypogonadism. Although obesity is associated with hypogonadism and is prevalent among type 2 diabetics, only 10-15 percent of the variation in low free testosterone levels could be attributable to body mass index, Dhindsa said. More than 30 percent of lean patients also were hypogonadal. "Equally important, most of the men who had low testosterone levels also had lower levels of gonadotrophins, as compared to men with normal testosterone levels," he noted. "Furthermore, the gonadotrophin concentration in the blood correlated positively with free testosterone levels, supporting the notion that the cause of the defect is in the pituitary or hypothalamus." The high prevalence of low testosterone in diabetic men is concerning, said Dhindsa, because in addition to lowered libido and erectile dysfunction, the condition is associated with loss of muscle tone, increase in abdominal fat, loss of bone density, and can affect mood and cognition. "Further studies will help us determine why type 2 diabetic patients are more prone to developing hypogonadism," he said. "While obesity may explain part of the high prevalence of hypogonadism, it is likely that other factors associated with type 2 diabetes also contribute significantly. This area is clearly ripe for further investigation." Additional researchers on the study were Sathyavani Prabhakar, M.D., UB clinical assistant instructor of medicine, Manak Sethi, M.D., research assistant, Arindam Bandyopadhyay, M.D., UB clinical assistant professor of medicine, and Ajay Chaudhuri, M.D., UB assistant professor of medicine. SOURCE: University at Buffalo

Wednesday, November 24, 2004

Healthspan Vitamin supplements. Buy tax-free vitamins online with Healthspan: "As always, Healthspan brings you the most 'advanced Glucosamine supplements' in the UK! Wherever and whenever there have been valuable advances in the science of nutrition, Healthspan have incorporated them into their 'advanced' range of products. We now offer liquid and vegetarian forms of Glucosamine. "

Friday, November 19, 2004

Letters to the Editor - January 15, 2004 - American Family Physician: "Use of Metformin Is a Cause of Vitamin B12 Deficiency"
Small studies and case reports have shown that 10 to 30 percent of patients who are prescribed metformin show signs of reduced vitamin B12 absorption leading to clinically significant abnormalities in about 30 percent of cases.

Friday, November 12, 2004

: "Title: AHA: Statins May Lower Blood Pressure
'AHA: Statins May Lower Blood Pressure'

By Charlene Laino NEW ORLEANS, LA -- November 10, 2004 -- Statin therapy leads to a significant reduction in diastolic and systolic blood pressure, a randomized, double-blind, placebo-controlled comparative trial shows. Beatrice A. Golomb, MD, PhD, associate professor of medicine, University of California, San Diego (UCSD), La Jolla, California, presented the results here on November 9[th at the American Heart Association Scientific Sessions 2004."

Close Control Of Blood Pressure Associated With Fewer Eye Problems In Patients With Type 2 Diabetes

Friday, November 05, 2004

Cookin' With Google -- ResearchBuzz, September 13, 2003: "Judy Hourihan came up with the idea of searching Google to figure out what you're going to have for dinner and I turned it into a Google Hack. one of the most popular ones out there.
"To use the recipe search, all you have to do is type a couple of ingredients in, and select the kind of recipe that you want. The service then searches Google to find recipes that match your specific criteria. You can even narrow things down to recipes for vegetarians, diabetics, and people on the Atkins Diet. When you only have a certain number of ingredients on hand, use Cookin’ With Google to figure out what’s for dinner.
Healthy Diabetic Recipes - a database of recipes suitable for diabetics
This is a GREAT site for any Diabetic (Including YOU Cath in Limassol)

Monday, November 01, 2004

BestTreatments :: Conditions :: Diabetes :: What treatments work?: "The different tablets used to treat diabetes can be divided into five groups. We have listed these below with some names of individual drugs (and brand names). Click on the links to find out more about:"
Diabetes, Foot Care and Foot Ulcers
PRODIGY PILS L541; (Version=23): "About 1 in 10 people with diabetes develop a foot ulcer at some stage. A foot ulcer is prone to infection, which may become severe. This leaflet aims to explain why foot ulcers sometimes develop, what you can do to help prevent them, and typical treatments if one does occur."
Type 2 Diabetes
PRODIGY PILS L49; (Version=24): "Type 2 diabetes occurs mainly in people aged over 40. The 'first-line' treatment is diet and exercise. If the blood glucose level remains high despite a trial of diet and exercise, then tablets to reduce the blood glucose level are usually advised. Insulin injections are needed in some cases. Other treatments include reducing blood pressure if it is high, and other measures to reduce the risk of complications."
Foot Care For People With Diabetes
PRODIGY PILS L540; (Version=23): "About 1 in 10 people with diabetes develop a foot ulcer at some stage. A foot ulcer does not heal very easily, is difficult to treat, and is prone to serious infection. Another leaflet called 'Diabetes, Foot Care and Foot Ulcers' gives more details. This leaflet gives a summary on how you can help to prevent foot ulcers."
Diabetic Retinopathy
And Other Eye Complications of Diabetes
PRODIGY PILS L584; (Version=23): "What is diabetic retinopathy?

What is diabetes?
Diabetes mellitus (just called diabetes from now on) occurs when the level of glucose (sugar) in the blood becomes higher than normal. There are two main types of diabetes - Type 1 and Type 2. See separate leaflets called 'Type 1 Diabetes' and 'Type 2 Diabetes' for more general information about diabetes."
Diabetes and High Blood Pressure
PRODIGY PILS L543; (Version=23): "Diabetes and High Blood Pressure"
What is high blood pressure?

High blood pressure (hypertension) means that the pressure of the blood in your arteries is too high. Blood pressure is recorded as two figures. For example, 140/80 mmHg. This is said as '140 over 80'. Blood pressure is measured in millimetres of mercury (mmHg).
Treatments for Type 2 Diabetes
PRODIGY PILS L583; (Version=23): "This leaflet mainly discuses treatments which can lower the blood glucose level. It briefly mentions other treatments which may also be advised if you have Type 2 diabetes. See a separate leaflet called 'Type 2 Diabetes' for more general information about this condition."
BBC NEWS | Health | Diabetics 'must test blood more': "Diabetics should be checking their blood sugar levels more regularly to reduce the risk of heart disease and strokes, US research shows."
BBC NEWS | Health | Herbal remedies 'do work': "cientific tests on a range of traditional remedies have shown they have 'real benefits', researchers say.

Experts from King's College London said the treatments from around the world had properties which may help treat conditions such as diabetes and cancer.

The remedies included India's curry leaf tree, reputed to treat diabetes."

Friday, October 29, 2004

RedNova - Deadly Threat of Diabetes: "EDDIE Cusack fears for the future when he looks around at the other people at his regular diabetes clinic. At 70, Eddie is pretty philosophical about developing type two diabetes, a condition which has traditionally been associated with getting older. As long as he is sensible about his diet and takes regular exercise, he should be able to control a serious illness which is potentially life- threatening."

Tuesday, October 19, 2004

Coenzyme Q10:

"High Cholesterol

Levels of CoQ10 tend to be lower in people with high cholesterol compared to healthy individuals of the same age. In addition, certain cholesterol-lowering drugs called statins (such as atorvastatin, cerivastatin, lovastatin, pravastatin, simvastatin) appear to deplete natural levels of CoQ10 in the body. Taking CoQ10 supplements can correct the deficiency caused by statin medications without affecting the medication's positive effects on cholesterol levels.


CoQ10 supplements may improve heart health and blood sugar and help manage high cholesterol and high blood pressure in individuals with diabetes. (High blood pressure, high cholesterol, and heart disease are all common problems associated with diabetes). Despite some concern that CoQ10 may cause a sudden and dramatic drop in blood sugar (called hypoglycemia), two recent studies of people with diabetes given CoQ10 two times per day showed no hypoglycemic response. The safest bet if you have diabetes is to talk to your doctor or registered dietitian about the possible use of CoQ10."
Coenzyme Q10: Questions and Answers, Cancer Facts 9.16
# What is Coenzyme Q10?

Coenzyme Q10 (also known as CoQ10, Q10, vitamin Q10, ubiquinone, or ubidecarenone) is a compound that is made naturally in the body. A coenzyme is a substance needed for the proper functioning of an enzyme, a protein that speeds up the rate at which chemical reactions take place in the body. The Q and the 10 in coenzyme Q10 refer to parts of the compound’s chemical structure.
Coenzyme Q10: "Heart disease. Cancer. AIDS. As unbelievable as it might sound, each of these deadly diseases often responds to a coenzyme Q10, a little known nutrient that can make a big difference in your health.

Granted, such 'cure all' statements leave people wondering whether CoQ10 is just the latest panacea of the month. Rest assured: the benefits of this nutrient are well documented in the medical journals. It's one of the most frequently prescribed heart 'drugs' in Japan and widely used in Europe-and one company even owns the patent for the CoQ10 treatment of AIDS.

Ask your doctor about CoQ10, though, and he'll probably say he's never heard of it. Part of the problem is CoQ10's name. 'Most doctors don't know what a coenzyme is,' said Karl Folkers, Ph.D., one of the researchers who pioneered CoQ10. Most biochemists know it as ubiquinone, an equally arcane name."

Wednesday, September 22, 2004

Pharmacists' Diabetes Services in Australia: "Objective: To implement and evaluate a specialized service for type 2 diabetes mellitus in the community pharmacy."
Advances in Diabetes for the Millennium: Insulin Treatment and Glucose Monitoring: "Newer insulins and easier blood glucose monitoring have greatly improved the ability to obtain excellent control of blood glucose levels with less risk of hypoglycemia. In type 1 diabetes, insulin pump therapy remains the optimal approach with the most flexibility, especially with the ultra-fast-acting analogs lispro or aspart. Otherwise, once- or twice-daily dosing with the long-acting analog glargine provides excellent basal coverage, and lispro or aspart at meals provides bolus coverage, all in the attempt to mimic physiological insulin secretion. For type 2 diabetes, although oral agents continue to be a mainstay of therapy, it is clear that many patients require insulin to attain the goal A1c of < 6.5%. Once-daily glargine is now used more commonly after 1-2 oral agents have failed, and it typically takes the place of sulfonylureas. The future will likely have better systems for continuous glucose monitoring and novel therapies to control glucose through agents that affect gut hormones."
Diabetics Exposed to Telmisartan and Enalapril
: "The first long-term study to compare an angiotensin receptor blocker (ARB) and an angiotensin-converting enzyme (ACE) inhibitor in patients with hypertension and early-stage type 2 diabetic nephropathy has shown that the ARB telmisartan and the ACE inhibitor enalapril have comparable long-term renoprotective effects.[1] The Diabetics Exposed to Telmisartan And Enalapril (DETAIL) trial is thus the first to show that an ARB offers renoprotection that is clinically equivalent to that of an ACE inhibitor."

Wednesday, September 15, 2004

: "There are many new orally administered agents to treat type 2 diabetes. Sulfonylureas and meglitinides stimulate insulin secretion. Metformin has been joined by thiazolidinediones to reduce insulin resistance. Disaccharidase inhibitors slow glucose uptake after a meal. Beta-3 agonists and agents that augment glucagon-like peptide activity are promising new agents in the effort to not only control glucose levels but also restrain weight gain. The future treatment of diabetes will require multiple drugs working in concert to normalize blood glucose."
Red Meat Increases Type 2 Diabetes Risk in Older Women: "NEW YORK (Reuters Health) Sept 09 - Middle age and elderly women with high levels of red meat in their diet appear to have an increased risk of developing type 2 diabetes, according to a study published in the September issue of Diabetes Care"

Tuesday, August 03, 2004

Low Glycemic Index Diet Helpful in Men With Type 2 Diabetes
August 2, 2004 — A low glycemic index (LGI) diet improves glycemic control, some lipid profiles, and fibrinolysis in men with type 2 diabetes, according to the results of a randomized trial published in the August issue of Diabetes Care

Monday, August 02, 2004

Twenty Percent of Patients With Asymptomatic Diabetes Have...
July 30, 2004 — Twenty percent of patients with asymptomatic diabetes have silent myocardial ischemia, according to the results of the Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects (DIAD) study published in the August issue of Diabetes Care. These findings support the American Diabetes Association (ADA) guidelines recommending routine screening.

Thursday, July 15, 2004

Wednesday, July 14, 2004

The Struggle for Mastery in Insulin Action:
ype 2 diabetes arises from a combination of impaired insulin action and defective pancreatic β-cell function. Classically, the two abnormalities have been viewed as distinct yet mutually detrimental processes. The combination of impaired insulin-dependent glucose metabolism in skeletal muscle and impaired β-cell function causes an increase of hepatic glucose production, leading to a constellation of tissue abnormalities that has been referred to as the diabetes "ruling triumvirate." Targeted mutagenesis in mice has led to a critical reappraisal of the integrated physiology of insulin action

Wednesday, July 07, 2004

Dual Blockade of Renin-Angiotensin System Renoprotective...: "Aug. 1, 2003 � Dual blockade of the renin-angiotensin system (RAS) is renoprotective in type 2 diabetes, according to the results of a double-blind, randomized trial published in the August issue of Diabetes Care. Adding an angiotensin II receptor blocker (ARB) to treatment with maximal recommended doses of an angiotensin-converting enzyme (ACE) inhibitor provided superior short-term renoprotection independent of systemic blood pressure changes."
Adding Thiazolidinedione to Metformin Plus Insulin Improves...: "July 1, 2004 � Adding thiazolidinedione to metformin (MET) plus insulin (INS) improved glycemic control and reduced INS dose without increasing weight gain, according to the results of a randomized trial published in the July issue of Diabetes Care. The editorialist suggests that treating to target is all that matters, regardless of what combination of medications is used. Cost and lifestyle should be considered in choosing optimal triple therapy."

Friday, July 02, 2004

News - Metformin Shows Promise for Diabetes Prevention, but Further Studies Needed
Metformin may help prevent type 2 diabetes in individuals at high risk of developing the disease, but new studies must evaluate its long-term safety, efficacy, cost-effectiveness, according to Donald L. Sullivan, PhD, RPh, and Aleda M. Hess, Pharm D, both of Ohio Northern University, Ada, United States.
News - Rosiglitazone Could Have Antiinflammatory Effects: "Thiazolidinedione rosiglitazone, a selective agonist of peroxisome proliferator-activated receptor gamma has demonstrated antiinflammatory effects, according to a new American study.

Troglitazone, a thiazolidinedione agonist of peroxisome proliferator-activated receptor gamma (PPAR�) and a partial agonist of PPAR�, was previously shown to have a significant antiinflammatory activity in a trial of diabetic obese patients and nondiabetic obese subjects, writes P. Mohanty, MD, and colleagues, Division of Endocrinology, Diabetes and Metabolism, State University of New York, New York."
Webcast/CME - Evolution of Type 2 Diabetes: The Time for Insulin is Now
This multi-media webcast reviews the goals of type 2 diabetes management, the benefits of intensive therapy, guidelines for measurement of glycaemic control, and practical strategies for helping achieve and maintain glycaemic control via intensive therapy methodologies
Adding Thiazolidinedione to Metformin Plus Insulin Improves...
July 1, 2004 — Adding thiazolidinedione to metformin (MET) plus insulin (INS) improved glycemic control and reduced INS dose without increasing weight gain, according to the results of a randomized trial published in the July issue of Diabetes Care. The editorialist suggests that treating to target is all that matters, regardless of what combination of medications is used. Cost and lifestyle should be considered in choosing optimal triple therapy.

Friday, June 11, 2004 - Diabetes Center
Rosuvastatin Label Change in EU Indicates Risk of Myopathy

June 10, 2004 — The U.S. Food and Drug Administration (FDA) issued a public health advisory yesterday, notifying healthcare professionals of labeling changes for rosuvastatin (Crestor, made by AstraZeneca) in the 22 member states of the European Union (EU). These changes, which are already in effect in FDA-approved labeling in the U.S., reflect the increased risk of myopathy associated with high levels of rosuvastatin.

Wednesday, June 09, 2004

Glucagon-like Peptide 1: Part II
The central role of GLP-1 in glucose tolerance has raised questions about the possible involvement of this peptide in the pathogenesis of diabetes. In addition, the wide range of coordinated actions by which GLP-1 lowers blood glucose has launched a new wave of drug development centered on this peptide hormone.

Incretin Hormones in Diabetes and Metabolism
The Incretin Effect
The Incretin Hormones: GIP and GLP-1
Incretin Physiology and Type 2 Diabetes Mellitus
Current Status of Drugs in Development
Concluding Remarks

Thursday, June 03, 2004

The Glycemic Index: "What is the Glycemic Index?
The glycemic index is a ranking of carbohydrates based on their immediate effect on blood glucose (blood sugar) levels. It compares foods gram for gram of carbohydrate. Carbohydrates that breakdown quickly during digestion have the highest glycemic indexes. The blood glucose response is fast and high. Carbohydrates that breakdown slowly, releasing glucose gradually into the blood stream, have low glycemic indexes."

Wednesday, June 02, 2004

ACE Inhibitors Improve Survival in Type 2 Diabetes: "May 27, 2004 � Angiotensin-converting enzyme (ACE) inhibitors significantly reduce all-cause mortality in patients with type 2 diabetes who do not have a history of cardiovascular disease, according to the results of a cohort study published in the June issue of Diabetes Care.
'ACE inhibitor therapy is widely used in lower-risk patients with type 2 diabetes to reduce mortality, despite limited evidence to support this clinical strategy,' write Dean T. Eurich, BSP, MSC, from the Institute of Health Economics in Edmonton, Alberta, Canada, and colleagues."

Saturday, May 29, 2004

ACE Inhibitors Improve Survival in Type 2 Diabetes

May 27, 2004 — Angiotensin-converting enzyme (ACE) inhibitors significantly reduce all-cause mortality in patients with type 2 diabetes who do not have a history of cardiovascular disease, according to the results of a cohort study published in the June issue of Diabetes Care.

Thursday, May 13, 2004

Aspirin-Like Treatment May Be Safe, Effective for Type 2 Diabetes
May 3, 2004 (Boston) — Salsalate, an aspirin-like anti-inflammatory agent, has shown promise as a type 2 diabetes treatment in a small pilot study at the Joslin Clinic.

Robert J. Silver, MD, a fellow in endocrinology and diabetes at the Boston-based diabetes center, reported that 3.0 g taken orally for two weeks was enough to reduce blood fasting glucose by 9% in nine patients. Other benefits included reductions of 12% in triglyceride and 15% in free fatty acid levels.

Monday, March 15, 2004

More Coffee, Less Diabetes - Diabetes Mellitus, Type 2, Type 1, and Metabolic Disorders treatment and medications
More Coffee, Less Diabetes
Authors' Conclusion: "Coffee drinking has a graded inverse association with the risk of type 2 DM; however, the reasons for this risk reduction associated with coffee remain unclear." (J. Tuomilehto and coauthors, JAMA. 2004;291:1213)

Our Translation: More coffee, less type 2 diabetes. We really have no idea why this is so.

Tuesday, March 02, 2004

Grapefruit Consumption Implicated in Case of Statin-Related Rhabdomyolysis: "Grapefruit Consumption Implicated in Case of Statin-Related Rhabdomyolysis

NEW YORK (Reuters Health) Mar 01 - A recent case of statin-associated rhabdomyolysis appears to have been triggered by grapefruit consumption, according to a report published in the February 24th issue of Neurology. Although the case involved simvastatin, the authors note that other statins could also be influenced by grapefruit consumption."

Tuesday, February 24, 2004

GLUCOPHAGE (metformin hydrochloride tablets)
GLUCOPHAGE XR (metformin hydrochloride
extended-release tablets)
Oral Antidiabetes Medications (FDA Consumer magazine, January-February 2002)

Wednesday, February 18, 2004

Thursday, February 12, 2004

Diabetes and Macrovascular Disease: Risk Factor Management
The Impact of Cardiovascular Disease
What We Know About the Endothelium
Vasculoprotection With Nitric Oxide
The Role of Oxidative Stress in Endothelial Dysfunction and Vascular Disease
The Renin-Angiotensin System: A Major Role in Endothelial Function
Putting It All Together: The Path to Coronary Artery Disease
Endothelial Dysfunction: Causes and Treatment Strategies
Plaque Pathology: An Inside View
Diabetes: A Source of Endothelial Insult
Reducing Macrovascular Complications: Evidence From the Statin Trials
More on the Vasculoprotective Effects of Lipid Lowering With Statins
Reducing Macrovascular Complications: Evidence From the Angiotensin-Converting Enzyme Inhibitor Trials
Findings From the Heart Outcomes Prevention Evaluation
Vasculoprotection With Angiotensin-Converting Enzyme Inhibitors
The Current Views on Risk Reduction Therapy

Wednesday, February 11, 2004

Cross-Talk Between Iron Metabolism and Diabetes
Emerging scientific evidence has disclosed unsuspected influences between iron metabolism and type 2 diabetes. The relationship is bi-directional—iron affects glucose metabolism, and glucose metabolism impinges on several iron metabolic pathways. Oxidative stress and inflammatory cytokines influence these relationships, amplifying and potentiating the initiated events. The clinical impact of these interactions depends on both the genetic predisposition and the time frame in which this network of closely related signals acts
Iron Stores in Healthy Women Linked to Diabetes Risk

Feb. 10, 2004 — Higher amounts of iron stores in the blood are associated with an increased risk of type 2 diabetes in healthy women with no known diabetes risk factors, according to the results of a nested case-control trial published in the Feb. 11 issue of The Journal of the American Medical Association.

Tuesday, February 03, 2004

Diabetes Care: Small-Bowel Bacterial Overgrowth in Diabetic Subjects Is Associated With Cardiovascular Autonomic Neuropathy.: "Gastrointestinal symptoms are present in 50-70% of patients with diabetes. Delayed gastric emptying, and disturbance of intestinal motility are frequent findings [1,2]. Impaired intestinal motility is often followed by small-bowel bacterial overgrowth (SBBO), which can possibly lead to deconjugation of bile acids, diarrhea, "

Monday, February 02, 2004

Medscape Resource Center - Diabetic Microvascular Complications: "Diabetes is, of course, a disease of complications. But landmark studies such as the Diabetes Control and Complication Trial have shown that achieving tight glycemic control can directly reduce the risk of diabetic complications, especially diabetic microvascular complications. New screening tools and potential new treatments also hold promise for making diabetic microvascular complications such as retinopathy and neuropathy more manageable and less inevitable."

Monday, January 26, 2004

Laxity in Diabetic Care in the US - Medical References for Patients

Quote: "If you're a diabetic over 55, you should be on an aspirin a day, a lipid-lowering agent [to lower cholesterol], and a medication to prevent heart attacks, like an ACE inhibitor. Heart attacks kill 80% of diabetics, and you can drop that by 70% by taking those three medications. You should therefore see your provider and discuss getting on them. Simple three pills, very safe and very simple, with almost no side effects. It could add years to your life." (Dr. R. James Dudi, Kaiser Permanente Health Plan, San Diego)

Wednesday, January 21, 2004

BBC NEWS | Health | Back pain drug 'may aid diabetics'

A drug used to treat backpain may also prevent patients with diabetes from going blind or having limbs amputated, a study suggests.
Scientists in the United States have found evidence to indicate that benfotiamine may be able to keep blood vessels healthy.

Saturday, January 03, 2004

The Five Absolute Worst Foods You Can Eat 10/18/03

By Dr. Joseph Mercola
with Rachael Droege

There are no “bad” foods, right? Only food you should eat in moderation? Well, not really. The following foods are so bad for your body that I really can’t see any reason to eat them. Not only do they have zero nutritional value, but they also give your body a healthy dose of toxins, which should make the idea of eating them really hard to swallow.